Catalog No.: PC-24286Not For Human Use, Lab Use Only.
IPA-3 is a selective, non-ATP competitive, covalent PAK1 inhibitor with IC50 of 2.5 uM, targets the PAK1 autoregulatory mechanism, and does not inhibit pre-activated PAK1.
IPA-3 is a selective, non-ATP competitive, covalent PAK1 inhibitor with IC50 of 2.5 uM, targets the PAK1 autoregulatory mechanism, and does not inhibit pre-activated PAK1. IPA-3 binds covalently to the Pak1 regulatory domain and prevents binding to the upstream activator Cdc42. IPA-3 inhibits all Group I Paks (PAK1-3), but not Group II Paks (PAK4-6). IPA-3 selectively inhibits Pak1 activation in mammalian cells.
Physicochemical Properties
M.Wt
350.45
Formula
C20H14O2S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,1'-Disulfanediylbis(naphthalen-2-ol)
References
1. Viaud J, et al. Mol Cancer Ther. 2009 Sep;8(9):2559-65.
2. Deacon SW, et al. Chem Biol. 2008 Apr;15(4):322-31.
