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IPAG

Chemical Structure : IPAG

CAS No.: 193527-91-2

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IPAG

Catalog No.: PC-60076Not For Human Use, Lab Use Only.

IPAG is a prototypic selective inhibitor of sigma1 receptor that engages the unfolded protein response and induces autophagy in cancer cells.

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25 mg $258 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IPAG is a prototypic selective inhibitor of sigma1 receptor that engages the unfolded protein response and induces autophagy in cancer cells.
IPAG induces autophagic degradation of PD-L1 in PC3 and MDA-MB-231 cells.

Physicochemical Properties

M.Wt 395.29
Formula C17H22IN3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

50 mM in ethanol;100 mM in DMSO
Chemical Name/SMILES

1-(4-Iodophenyl)-3-(2-adamantyl)guanidine

References

1. Wilson AA, et al. J Med Chem. 1991 Jun;34(6):1867-70.

2. Whittemore ER, et al. J Pharmacol Exp Ther. 1997 Jul;282(1):326-38.

3. Schrock JM, et al. Mol Pharmacol. 2013 Nov;84(5):751-62.

4. Maher CM, et al. Mol Cancer Res. 2017 Nov 8. pii: molcanres.0166.2017.

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