IPI-3063 is apotent, and selective p110δ PI3K inhibitor with IC50 of 0.1 nM in cell-based assays.
IPI-3063 displays >100-fold selectivity over p110α, p110β and p110γ.
IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1.
IPI-3063 potently inhibits human B cell proliferation in vitro at 10 nM, but not the p110γ selective inhibitor AS-252424.
