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Chemical Structure : IPI-3063
Catalog No.: PC-60565Not For Human Use, Lab Use Only.
A novel, potent, and selective p110δ PI3K inhibitor with IC50 of 0.1 nM in cell-based assays.
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A novel, potent, and selective p110δ PI3K inhibitor with IC50 of 0.1 nM in cell-based assays; displays >100-fold selectivity over p110α, p110β and p110γ; potently reduces mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1; potently inhibits human B cell proliferation in vitro at 10 nM, but not the p110γ selective inhibitor AS-252424.
| M.Wt | 455.522 | |
| Formula | C25H25N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chiu H, et al. Front Immunol. 2017 Jun 30;8:747.
2. Winkler DG, et al. Chem Biol. 2013 Nov 21;20(11):1364-74.
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