IPI-443 | Probechem Biochemicals

Chemical Structure : IPI-443

IPI-443 (IPI 443, IPI443)

Catalog No.: PC-60566Not For Human Use, Lab Use Only.

A potent, selective, orally active p110δ/γ PI3K dual inhibitor with cellular IC50 of 0.29 and 7.1 nM, respectively.

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Biological Activity

IPI-443 is a potent, selective, orally active p110δ/γ PI3K dual inhibitor with cellular IC50 of 0.29 and 7.1 nM, respectively.
IPI-443 displays >600-fold selectivity over p110α and p110β.
IPI-443 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1。
IPI-443 potently inhibits human B cell proliferation in vitro at 10 nM, but not the p110γ selective inhibitor AS-252424.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

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IPI-443 (IPI 443, IPI443)

Biological Activity

Physicochemical Properties

References

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