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Chemical Structure : IPI-443
Catalog No.: PC-60566Not For Human Use, Lab Use Only.
A potent, selective, orally active p110δ/γ PI3K dual inhibitor with cellular IC50 of 0.29 and 7.1 nM, respectively.
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A potent, selective, orally active p110δ/γ PI3K dual inhibitor with cellular IC50 of 0.29 and 7.1 nM, respectively; displays >600-fold selectivity over p110α and p110β; potently reduces mouse B cell proliferation, survival, and plasmablast differentiation while increasing antibody class switching to IgG1; potently inhibits human B cell proliferation in vitro at 10 nM, but not the p110γ selective inhibitor AS-252424.
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| Appearance | Solid | |
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10 mM in DMSO |
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