IPI-9119 (IPI9119) is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.3 nM in biochemical assays.
IPI-9119 inhibits PCa cell growth and induces cell cycle arrest and apoptosis, induces a profound metabolic reprogramming in PCa cells.
IPI-9119 also inhibits AR-FL and AR-V7 protein expression and induces ER stress response and protein translation inhibition, inhibits AR transcriptional activity and enhances enzalutamide efficacy in CRPC cells.
IPI-9119 inhibits tumor growth of CRPC xenografts and human mCRPC-derived organoids.
