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Chemical Structure : IPP-14
Catalog No.: PC-62552Not For Human Use, Lab Use Only.
IPP-14 is a novel PAK1 inhibitor that selectively blocks the PAK1-PUMA binding and suppresses cell proliferation via PUMA-dependent manner.
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IPP-14 (Inhibitor of PAK1-PUMA) is a novel PAK1 inhibitor that selectively blocks the PAK1-PUMA binding and suppresses cell proliferation via PUMA-dependent manner.
IPP-14 suppresses cancer cell viability and migration, induces p21 expression and induces M-phase arrest by inhibition of PAK1.
IPP-14 also induces p21/WAF1/CIP1 (Cyclin-dependent kinase inhibitor 1A) expression by releasing from Bcl-2 and by inhibition of AKT-mediated p21 suppression.
| M.Wt | 468.572 | |
| Formula | C24H28N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Woo TG, et al. Oncotarget. 2017 Apr 4;8(14):23690-23701.
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