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IPP-14

Chemical Structure : IPP-14

CAS No.:

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IPP-14 (IPP14, Inhibitor of PAK1-PUMA)

Catalog No.: PC-62552Not For Human Use, Lab Use Only.

IPP-14 is a novel PAK1 inhibitor that selectively blocks the PAK1-PUMA binding and suppresses cell proliferation via PUMA-dependent manner.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IPP-14 (Inhibitor of PAK1-PUMA) is a novel PAK1 inhibitor that selectively blocks the PAK1-PUMA binding and suppresses cell proliferation via PUMA-dependent manner.
    IPP-14 suppresses cancer cell viability and migration, induces p21 expression and induces M-phase arrest by inhibition of PAK1.
    IPP-14 also induces p21/WAF1/CIP1 (Cyclin-dependent kinase inhibitor 1A) expression by releasing from Bcl-2 and by inhibition of AKT-mediated p21 suppression.

    Physicochemical Properties

    M.Wt 468.572
    Formula C24H28N4O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-N-hydroxy-4-(2-methyl-3-((6-(2-morpholinoethoxy)benzo[d]thiazol-2-yl)amino)prop-1-en-1-yl)benzamide

    References

    1. Woo TG, et al. Oncotarget. 2017 Apr 4;8(14):23690-23701.

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