Catalog No.: PC-20121Not For Human Use, Lab Use Only.
IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain).
IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain).
IPPQ inhibited CaV2.2 currents in sensory neurons.
IPPQ inhibited pre-synaptic localization of CaV2.2 in vivo.
IPPQ inhibited spinal neurotransmission, which resulted in decreased neurotransmitter release.
IPPQ exhibited anti-nociceptive effect in naïve rats and reversed mechanical allodynia and thermal hyperalgesia in rodent models of acute, neuropathic, and genetic pain.
