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Chemical Structure : IPPQ
Catalog No.: PC-20121Not For Human Use, Lab Use Only.
IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain).
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IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain).
IPPQ inhibited CaV2.2 currents in sensory neurons.
IPPQ inhibited pre-synaptic localization of CaV2.2 in vivo.
IPPQ inhibited spinal neurotransmission, which resulted in decreased neurotransmitter release.
IPPQ exhibited anti-nociceptive effect in naïve rats and reversed mechanical allodynia and thermal hyperalgesia in rodent models of acute, neuropathic, and genetic pain.
| M.Wt | 429.52 | |
| Formula | C25H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dongzhi Ran, et al. Channels (Austin). 2021 Dec;15(1):128-135.
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