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Chemical Structure : IQ-1S
CAS No.: 23146-22-7
Catalog No.: PC-42095Not For Human Use, Lab Use Only.
IQ-1S is a potent, highly specific JNK inhibitor with IC50 of 390, 360, and 87 nM for JNK1, JNK2, and JNK3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $178 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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IQ-1S is a potent, highly specific JNK inhibitor with IC50 of 390, 360, and 87 nM for JNK1, JNK2, and JNK3, respectively.
IQ-1S does not inhibits other kinases that represent potential targets for RA treatment, including GSK-3beta, JAK2, JAK3, PI3Ks, Btk, IKK-2, etc.
IQ-1S inhibits pro-inflammatory cytokine (IL-1α, IL-1β, IL-6, IL-10, TNF-α, IFN-γ, and GM-CSF and nitric oxide production by human and murine monocyte/macrophages.
IQ-1S inhibits LPS-induced TNF-α and IL-6 production in MonoMac-6 cells with IC50 of 0.25 and 0.61 uM, respectively.
IQ-1S reduces inflammation and cartilage loss associated with CIA in mice model.
| M.Wt | 247.2515 | |
| Formula | C15H9N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
11H-Indeno[1,2-b]quinoxalin-11-one, oxime |
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1. Schepetkin IA, et al. Mol Pharmacol. 2012 Jun;81(6):832-45.
2. Schepetkin IA, et al. J Pharmacol Exp Ther. 2015 Jun;353(3):505-16.
3. Atochin DN, et al. Neurosci Lett. 2016 Apr 8;618:45-49.
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