IQ-1S |CAS:23146-22-7 Probechem Biochemicals

Chemical Structure : IQ-1S

CAS No.: 23146-22-7

IQ-1S (IQ 1S free acid)

Catalog No.: PC-42095Not For Human Use, Lab Use Only.

IQ-1S is a potent, highly specific JNK inhibitor with IC50 of 390, 360, and 87 nM for JNK1, JNK2, and JNK3, respectively.

Packing	Price	Stock
25 mg	$178	In stock
50 mg	$298	In stock
100 mg	$498	In stock
200 mg		Get quote
1 g		Get quote

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Biological Activity

IQ-1S is a potent, highly specific JNK inhibitor with IC50 of 390, 360, and 87 nM for JNK1, JNK2, and JNK3, respectively.
IQ-1S does not inhibits other kinases that represent potential targets for RA treatment, including GSK-3beta, JAK2, JAK3, PI3Ks, Btk, IKK-2, etc.
IQ-1S inhibits pro-inflammatory cytokine (IL-1α, IL-1β, IL-6, IL-10, TNF-α, IFN-γ, and GM-CSF and nitric oxide production by human and murine monocyte/macrophages.
IQ-1S inhibits LPS-induced TNF-α and IL-6 production in MonoMac-6 cells with IC50 of 0.25 and 0.61 uM, respectively.
IQ-1S reduces inflammation and cartilage loss associated with CIA in mice model.

Physicochemical Properties

M.Wt	247.2515
Formula	C15H9N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	11H-Indeno[1,2-b]quinoxalin-11-one, oxime

References

1. Schepetkin IA, et al. Mol Pharmacol. 2012 Jun;81(6):832-45.

2. Schepetkin IA, et al. J Pharmacol Exp Ther. 2015 Jun;353(3):505-16.

3. Atochin DN, et al. Neurosci Lett. 2016 Apr 8;618:45-49.

IQ-1S (IQ 1S free acid)

Biological Activity

Physicochemical Properties

References

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