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IQZ-1

Chemical Structure : IQZ-1

CAS No.: 1110874-39-9

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IQZ-1 (IQZ1)

Catalog No.: PC-27174Not For Human Use, Lab Use Only.

IQZ-1 is a small molecule inhibitor of fatty acid synthase (FASN) expression with IC50 of 0.6 uM in HuH-7 cells, inhibits FASN transcription at least via the proximal sterol regulatory elements of the FASN promoter.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IQZ-1 is a small molecule inhibitor of fatty acid synthase (FASN) expression with IC50 of 0.6 uM in HuH-7 cells, inhibits FASN transcription at least via the proximal sterol regulatory elements of the FASN promoter.
    IQZ-1 significantly reduces HCV intracellular viral RNA levels and markedly suppresses infectious particle production.

    Physicochemical Properties

    M.Wt 427.46
    Formula C22H25N3O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((4-hydroxy-5,8-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-6,7-dimethoxyquinazolin-4(3H)-one

    References

    1. Wang X, et al. Biochem Biophys Res Commun. 2026 Jun 22;829:154182.

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