Chemical Structure : IR-IGF-1R heterodimer modulator HI-2
CAS No.:
IR-IGF-1R heterodimer modulator HI-2
Catalog No.: PC-23218Not For Human Use, Lab Use Only.
HI-2 is a small molecule modulator of insulin receptor-insulin like growth factor-1 receptor heterodimers, inhibits insulin receptor/IGF-1 receptor hybrid formation, with no effects on IR or IGF-1R.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HI-2 is a small molecule modulator of insulin receptor-insulin like growth factor-1 receptor heterodimers, inhibits insulin receptor/IGF-1 receptor hybrid formation, with no effects on IR or IGF-1R.
HI-2 reduced expression of the negative regulatory p85α subunit of phosphatidylinositol 3-kinase, increased basal phosphorylation of the downstream target Akt and enhanced insulin/insulin-like growth factor-1 and shear stress-induced serine phosphorylation of Akt.
HI-2 significantly reduced hybrid expression in saphenous vein endothelial cells (SVEC) from patients with type 2 diabetes mellitus.
Physicochemical Properties
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M.Wt
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433.52
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Formula
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C27H23N5O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(1-(3-methylbenzyl)-1H-1,2,4-triazol-3-yl)-2-(p-tolyl)quinoline-4-carboxamide
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References
1. Myers CG, et al. Mol Cell Endocrinol. 2024 Oct 15:112387.
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