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Chemical Structure : IR-IGF-1R heterodimer modulator HI-2
Catalog No.: PC-23218Not For Human Use, Lab Use Only.
HI-2 is a small molecule modulator of insulin receptor-insulin like growth factor-1 receptor heterodimers, inhibits insulin receptor/IGF-1 receptor hybrid formation, with no effects on IR or IGF-1R.
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HI-2 is a small molecule modulator of insulin receptor-insulin like growth factor-1 receptor heterodimers, inhibits insulin receptor/IGF-1 receptor hybrid formation, with no effects on IR or IGF-1R.
HI-2 reduced expression of the negative regulatory p85α subunit of phosphatidylinositol 3-kinase, increased basal phosphorylation of the downstream target Akt and enhanced insulin/insulin-like growth factor-1 and shear stress-induced serine phosphorylation of Akt.
HI-2 significantly reduced hybrid expression in saphenous vein endothelial cells (SVEC) from patients with type 2 diabetes mellitus.
| M.Wt | 433.52 | |
| Formula | C27H23N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Myers CG, et al. Mol Cell Endocrinol. 2024 Oct 15:112387.
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