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Chemical Structure : IR415
CAS No.: 452967-14-5
Catalog No.: PC-63405Not For Human Use, Lab Use Only.
IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression, reverses the inhibitory effect of HBx protein on activity of the Dicer endoribonuclease.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression, reverses the inhibitory effect of HBx protein on activity of the Dicer endoribonuclease.
IR415 exhibits a marked depletion of HBV core protein synthesis and down-regulation of pre-genomic HBV RNA in HBV-infected HepG2 cells.
IR415 selectively targets HBx in a concentration-dependent manner.
| M.Wt | 296.34 | |
| Formula | C13H14F2N4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2,4-difluorophenyl)-N'-[3-(1H-imidazol-1-yl) propyl] thiourea |
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1. Ghosh S, et al. J Biol Chem. 2017 Jul 28;292(30):12577-12588.
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