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IRAK4-IN-16

Chemical Structure : IRAK4-IN-16

CAS No.: 509093-72-5

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IRAK4-IN-16 (IRAK4 inhibitor 16)

Catalog No.: PC-60980Not For Human Use, Lab Use Only.

IRAK4-IN-16 is a potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IRAK4-IN-16 is a potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively.
    IRAK4-IN-16 inhibits IL-1 induced activation of NF-kB in primary human monocytes with IC50 of 0.3 uM.
    IRAK4-IN-16 possesses excellent selectivity and pharmacokinetic properties.

    Physicochemical Properties

    M.Wt 478.519
    Formula C27H25F3N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1-phenyl-5-(piperidin-1-ylmethyl)-1H-benzo[d]imidazol-2-yl)-3-(trifluoromethyl)benzamide

    References

    1. Wang Z, et al. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5546-50.

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