IRAK4 inhibitor 23 | IRAK4 inhibitor | Probechem Biochemicals

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Chemical Structure : IRAK4 inhibitor 23

CAS No.: 1820787-94-7

IRAK4 inhibitor 23 (IRAK4-IN-1)

Catalog No.: PC-61623Not For Human Use, Lab Use Only.

IRAK4 inhibitor 23 is a potent, selective, orally bioavailable IRAK4 inhibitor with IC50 of 7 nM.

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5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$428	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IRAK4 inhibitor 23 is a potent, selective, orally bioavailable IRAK4 inhibitor with IC50 of 7 nM.
IRAK4 inhibitor 23 inhibits R848 (TLR7 agonist) stimulated cytokine release in hPBMC with IC50 of 300 nM.
IRAK4 inhibitor 23 exhibits excellent pharmacokinetic profile and kinase selectivity (99%).
IRAK4 inhibitor 23 demonstrates activity in vivo via oral dosing in TLR7 driven model of inflammation.

Physicochemical Properties

M.Wt	337.427
Formula	C19H23N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((1r,4r)-4-morpholinocyclohexyl)amino)quinazoline-6-carbonitrile

References

1. Smith GF, et al. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2721-2726.

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IRAK4 inhibitor 23 (IRAK4-IN-1)

Biological Activity

Physicochemical Properties

References

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