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IRAK inhibitor 1

Chemical Structure : IRAK inhibitor 1

CAS No.: 1042224-63-4

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IRAK inhibitor 1 (IRAK4 inhibitor 1)

Catalog No.: PC-43454Not For Human Use, Lab Use Only.

IRAK inhibitor 1 is a potent IRAK4 inhibitor with IC50 of 216 nM, shows little to no activity against JNK-1 and JNK-2 with IC50 of 3.801 uM and >10 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IRAK inhibitor 1 is a potent IRAK4 inhibitor with IC50 of 216 nM, shows little to no activity against JNK-1 and JNK-2 with IC50 of 3.801 uM and >10 uM, respectively.

Physicochemical Properties

M.Wt 293.37
Formula C17H19N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 12.2 mg/mL
Chemical Name/SMILES

2-Pyridinamine, 6-imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-

References

1. Buckley GM, et al. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3291-5.

2. Li S, et al. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5567-72.

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