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IRAP-IN-1

Chemical Structure : IRAP-IN-1

CAS No.: 2007955-25-9

IRAP-IN-1 (IRAP inhibitor)

Catalog No.: PC-72273Not For Human Use, Lab Use Only.

IRAP-IN-1 is a selective insulin-regulated aminopeptidase (IRAP) inhibitor with IC50 of 32 nM, >25-fold selectivity over ERAP1 and ERAP2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IRAP-IN-1 is a selective insulin-regulated aminopeptidase (IRAP) inhibitor with IC50 of 32 nM, >25-fold selectivity over ERAP1 and ERAP2.
    IRAP-IN-1 reduces IRAP-dependent but not ERAP1-dependent cross-presentation by dendritic cells with nanomolar efficacy.

    Physicochemical Properties

    M.Wt 597.696
    Formula C35H40N3O4P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    ((S)-2-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-4,4-diphenylbutyl)((R)-1-amino-3-phenylpropyl)phosphinic acid

    References

    1. Paraskevi Kokkala, et al. J Med Chem. 2016 Oct 13;59(19):9107-9123.

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