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IRBM-Z-1

Chemical Structure : IRBM-Z-1

CAS No.: 67629-86-1

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IRBM-Z-1

Catalog No.: PC-26056Not For Human Use, Lab Use Only.

IRBM-Z-1 is a non-competitive allosteric inhibitor of ZIKV NS3 protease with IC50 of 1.8 uM (wt NS2B-NS3 protease), exhibits ZIKV antiinfectivity activity in cell culture assays with EC50 of 6.25 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IRBM-Z-1 is a non-competitive allosteric inhibitor of ZIKV NS3 protease with IC50 of 1.8 uM (wt NS2B-NS3 protease), exhibits ZIKV antiinfectivity activity in cell culture assays with EC50 of 6.25 uM.
The I156T mutation in NS3, strongly reduced the inhibitory effect of IRBM-Z-1, in both the enzymatic and replicon assays.
IRBM-Z-1 exhibited a dissociation constant (KD) of 1.52 uM for ZIKV NS3 protease.

Physicochemical Properties

M.Wt 390.37
Formula C19H17F3N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,2,3-Oxadiazolium, 3-(1-methyl-2-phenylethyl)-5-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-, inner salt

References

1. Ontoria JM, et al. Nat Commun. 2026 Feb 10;17(1):1439.

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