Catalog No.: PC-23819Not For Human Use, Lab Use Only.
IRL-2500 (IRL 2500) is a potent and selective endothelin-B receptor (ETB) antagonist, inhibits binding of [125I]-endothelin-1 (ET-1) to human ETB with IC50 of 1.3 nM, 70-fold selective over ETA receptor.
IRL-2500 (IRL 2500) is a potent and selective endothelin-B receptor (ETB) antagonist, inhibits binding of [125I]-endothelin-1 (ET-1) to human ETB with IC50 of 1.3 nM, 70-fold selective over ETA receptor. IRL 2500 inhibited the sarafotoxin S6c (STX6c)-mediated contraction of the dog saphenous vein (pKb 7.77) and the STX6c-induced relaxation of the preconstricted rabbit mesenteric artery (pKb 6.92) IRL 2500 (10 mg/kg, i.v.) inhibited the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 (0.5 nmol/kg, i.v.) in anesthetized rats. IRL 2500 (10 mg/kg, i.v.) inhibited the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 (0.5 nmol/kg, i.v.).
