Catalog No.: PC-20103Not For Human Use, Lab Use Only.
IRL1620 (IRL-1620, Sovateltide, PMZ-1620) is a potent, selective agonist for endothelin ETB receptor with Ki of 0.016 nM, highly selective over ETA receptor (Ki=1900 nM).
IRL1620 (IRL-1620, Sovateltide, PMZ-1620) is a potent, selective agonist of endothelin ETB receptor with Ki of 0.016 nM, highly selective over ETA receptor (Ki=1900 nM).
IRL-1620 prevents oxidative stress and cognitive impairment induced by Aβ in normal and diabetic rats.
IRL-1620 shows neuroprotective effect in rat brain ischemia model, increases angiogenesis and neurogenesis, and promotes the recovery of neuronal function.
IRL-1620 also promotes neural progenitor cell differentiation and maturation in vitro and in vivo.
Physicochemical Properties
M.Wt
1820
Formula
C86H117N17O27
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Succinyl-(Glu9,Ala11,15)-Endothelin-1 (8-21)
References
1. Yukimura T, et al. Eur J Pharmacol. 1994 Nov 3;264(3):399-405.
2. Kobari M, et al. Neurosci Lett. 1994 Aug 1;176(2):157-60.
