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Chemical Structure : ISCK03
CAS No.: 945526-43-2
Catalog No.: PC-42389Not For Human Use, Lab Use Only.
ISCK03 is a specific c-Kit inhibitor that inhibits c-kit phosphorylation in vitro and SCF-induced c-kit phosphorylation in human melanoma cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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ISCK03 is a specific c-Kit inhibitor that inhibits c-kit phosphorylation in vitro and SCF-induced c-kit phosphorylation in human melanoma cells.
ISCK03 also inhibits p44/42 ERK mitogen-activated protein kinase (MAPK) phosphorylation, does not inhibit HGF-induced phosphorylation of p44/42 ERK proteins.
ISCK03 induces the dose-dependent depigmentation of newly regrown hair, promotes the depigmentation of UV-induced hyperpigmented spots in vivo; orally acitve.
| M.Wt | 355.45394 | |
| Formula | C19H21N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 38 mg/mL |
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| Chemical Name/SMILES |
Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- |
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1. Na YJ, et al. Biochem Pharmacol. 2007 Sep 1;74(5):780-6.
2. Kamlah F, et al. Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1541-9.
3. Hirano T, et al. Mol Cancer. 2015 Apr 19;14:90.
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