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Chemical Structure : ISRIB
CAS No.: 548470-11-7
Catalog No.: PC-38450Not For Human Use, Lab Use Only.
cis-ISRIB is a weak inhibitor of PERK signaling compared to trans-ISRIB , potently reverses the effects of eIF2α phosphorylation with IC50 of 600 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $398 | In stock | |
| 250 mg | Get quote |
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ISRIB is a weak inhibitor of PERK signaling compared to trans-ISRIB , potently reverses the effects of eIF2α phosphorylation with IC50 of 600 nM.
ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, displays significant enhancement in spatial and fear-associated learning.
ISRIB is a potent inhibitor of the integrated stress response (ISR)integrated stress response (ISR).
| M.Wt | 451.34 | |
| Formula | C22H24Cl2N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N,N′-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide] |
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1. Sidrauski C, et al. Elife. 2015 Feb 26;4:e05033.
2. Sidrauski C, et al. Elife. 2013 May 28;2:e00498.
3. Halliday M, et al. Cell Death Dis. 2015 Mar 5;6:e1672.
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