IST5-002
(Inhibitor of Stat5-002, N6-Benzyladenosine-5'-phosphate)
Catalog No.: PC-20634Not For Human Use, Lab Use Only.
IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells.
IST5-002 is a specific small molecule taregeting STAT5 SH2-domain, inhibits both Stat5a/b phosphorylation and dimerization, robustly inhibits transcriptional activity of Stat5a (IC50=1.5 μM) and Stat5b (IC50=3.5 μM) in PC-3 cells.
IST5-002 blocks Bcr-Abl-induced Stat5a/b phosphorylation at 5 μM in Bcr-Abl-positive K562 cells.
IST5-002 blocks phosphorylation of Stat5a/b (CWR22Rv1, IC50=22 μM; HC-11, IC50=12 μM; T47D, IC50=24.8 μM), while total Stat5a/b levels remains unaffected.
IST5-002 shows no specific inhibition of other kinases in a panel of 50 kinases, does not block transcriptional activity of Stat3.
IST5-002 suppresses downstream signaling events and target gene expression induced by Stat5a/b in PC and CML cells.
IST5-002 suppresses Stat5a/b-mediated growth of PC through induction of apoptosis in experimental models of PC in vitro, in vivo and ex vivo.
