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ISX-9

Chemical Structure : ISX-9

CAS No.: 832115-62-5

ISX-9 (Isoxazole 9)

Catalog No.: PC-42974Not For Human Use, Lab Use Only.

ISX-9 (Isoxazole 9) is a isoxazole stem cell-modulator small molecule and GPR68 ligand through a chemical biology-target discovery strategy to GPR68, a proton (pH) sensing G protein-coupled receptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ISX-9 (Isoxazole 9) is a isoxazole stem cell-modulator small molecule and GPR68 ligand through a chemical biology-target discovery strategy to GPR68, a proton (pH) sensing G protein-coupled receptor.
ISX-9  induces neuronal differentiation of GPR68-expressing cells in hippocampus and primary cultures.
ISX-9 and GPR68 coregulates neuronal target genes such as Bex1 (brain-enriched X-linked protein-1) in hippocampal neural progenitors (HCN cells).
ISX-9  pharmacologically targets type 1 neural stem cells (NSCs), promoting neurogenesis in young mice, depleting the progenitor pool without adversely affecting hippocampal learning and memory function.

Physicochemical Properties

M.Wt 234.2743
Formula C11H10N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 37 mg/mL

Chemical Name/SMILES

3-Isoxazolecarboxamide, N-cyclopropyl-5-(2-thienyl)-

References

1. Schneider JW, et al. ACS Chem Neurosci. 2012 Jul 18;3(7):557-68.

2. Schneider JW, et al. Nat Chem Biol. 2008 Jul;4(7):408-10.

3. Bettio LE, et al. Neuroscience. 2016 Sep 22;332:212-22.

4. Bettio LEB, et al. Neurogenesis (Austin). 2017 Jun 1;4(1):e1317692.

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