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Chemical Structure : ISX-9
CAS No.: 832115-62-5
Catalog No.: PC-42974Not For Human Use, Lab Use Only.
ISX-9 (Isoxazole 9) is a isoxazole stem cell-modulator small molecule and GPR68 ligand through a chemical biology-target discovery strategy to GPR68, a proton (pH) sensing G protein-coupled receptor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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ISX-9 (Isoxazole 9) is a isoxazole stem cell-modulator small molecule and GPR68 ligand through a chemical biology-target discovery strategy to GPR68, a proton (pH) sensing G protein-coupled receptor.
ISX-9 induces neuronal differentiation of GPR68-expressing cells in hippocampus and primary cultures.
ISX-9 and GPR68 coregulates neuronal target genes such as Bex1 (brain-enriched X-linked protein-1) in hippocampal neural progenitors (HCN cells).
ISX-9 pharmacologically targets type 1 neural stem cells (NSCs), promoting neurogenesis in young mice, depleting the progenitor pool without adversely affecting hippocampal learning and memory function.
| M.Wt | 234.2743 | |
| Formula | C11H10N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 37 mg/mL |
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| Chemical Name/SMILES |
3-Isoxazolecarboxamide, N-cyclopropyl-5-(2-thienyl)- |
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1. Schneider JW, et al. ACS Chem Neurosci. 2012 Jul 18;3(7):557-68.
2. Schneider JW, et al. Nat Chem Biol. 2008 Jul;4(7):408-10.
3. Bettio LE, et al. Neuroscience. 2016 Sep 22;332:212-22.
4. Bettio LEB, et al. Neurogenesis (Austin). 2017 Jun 1;4(1):e1317692.
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