IT-901 | c-Rel/NF-κB inhibitor | Probechem Biochemicals

Chemical Structure : IT-901

CAS No.: 1584121-99-2

IT-901 (IT 901, IT901)

Catalog No.: PC-61961Not For Human Use, Lab Use Only.

IT-901 is a novel potent, small molecule inhibitor of NF-κB subunit c-Rel, inhibits DNA binding of c-Rel and NF-κB activity with IC50 of 3 uM.

Packing	Price	Stock
5 mg	$288	In stock
10 mg	$458	In stock
25 mg	$728	In stock
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Biological Activity

IT-901 is a novel potent, small molecule inhibitor of NF-κB subunit c-Rel, inhibits DNA binding of c-Rel and NF-κB activity with IC50 of 3 uM.
IT-901 reduces stimulation of the oxidative stress response gene heme oxygenase-1.
IT-901 inhibits c-Rel/NF-κB both in vitro and in vivo.

Physicochemical Properties

M.Wt	342.37
Formula	C17H14N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(2,4-dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione

References

1. Shono Y, et al. Cancer Res. 2016 Jan 15;76(2):377-89.

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IT-901 (IT 901, IT901)

Biological Activity

Physicochemical Properties

References

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