Chemical Structure : ITI-333
CAS No.:
2117619-00-6
ITI-333
(ITI 333)
Catalog No.: PC-22332Not For Human Use, Lab Use Only.
ITI-333 is a potent, brain-penetrant, orally bioavailable 5-HT2A receptor antagonist (Ki =8 nM) and a biased, partial agonist at μ-opioid (MOP) receptors (Ki =11 nM, lacking β-arrestin agonism).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ITI-333 is a potent, brain-penetrant, orally bioavailable 5-HT2A receptor antagonist (Ki =8 nM) and a biased, partial agonist at μ-opioid (MOP) receptors (Ki =11 nM, lacking β-arrestin agonism).
ITI-333 also displays antagonist activity at adrenergic α1A (Ki = 28 nM) and dopamine D1 (Ki=50 nM) receptors.
ITI-333 displays properties anticipated to aid in opioid withdrawal and prevent opioid relapse for sustainable long-term recovery.
ITI-333 has a low liability for abuse and safety issues in self-administration, physical tolerance/dependence, and gastrointestinal (GI) and pulmonary function assays.
Physicochemical Properties
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M.Wt
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381.45
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Formula
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C22H24FN3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(6bR,10aS)-8-[3-(4-fluorophenoxy)propyl]-6b,7,8,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-2(3H)-one
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References
1. Gretchen L Snyder, et al. Psychopharmacology (Berl). 2024 May 6. doi: 10.1007/s00213-024-06578-w
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