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Chemical Structure : ITI-333
Catalog No.: PC-22332Not For Human Use, Lab Use Only.
ITI-333 is a potent, brain-penetrant, orally bioavailable 5-HT2A receptor antagonist (Ki =8 nM) and a biased, partial agonist at μ-opioid (MOP) receptors (Ki =11 nM, lacking β-arrestin agonism).
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ITI-333 is a potent, brain-penetrant, orally bioavailable 5-HT2A receptor antagonist (Ki =8 nM) and a biased, partial agonist at μ-opioid (MOP) receptors (Ki =11 nM, lacking β-arrestin agonism).
ITI-333 also displays antagonist activity at adrenergic α1A (Ki = 28 nM) and dopamine D1 (Ki=50 nM) receptors.
ITI-333 displays properties anticipated to aid in opioid withdrawal and prevent opioid relapse for sustainable long-term recovery.
ITI-333 has a low liability for abuse and safety issues in self-administration, physical tolerance/dependence, and gastrointestinal (GI) and pulmonary function assays.
| M.Wt | 381.45 | |
| Formula | C22H24FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gretchen L Snyder, et al. Psychopharmacology (Berl). 2024 May 6. doi: 10.1007/s00213-024-06578-w
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