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ITK inhibitor C-161

Chemical Structure : ITK inhibitor C-161

CAS No.: 2616666-32-9

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ITK inhibitor C-161

Catalog No.: PC-24846Not For Human Use, Lab Use Only.

ITK inhibitor C-161 is a potent, selective ITK kinase inhibitor with SPR Kd of 387 nM, dose-dependently inhibits IL-2 expression with IC50 of 494 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ITK inhibitor C-161 is a potent, selective ITK kinase inhibitor with SPR Kd of 387 nM, dose-dependently inhibits IL-2 expression with IC50 of 494 nM.
C-161 attenuated Th2 and Th17 differentiation in vitro.
C-161 administration ameliorated asthma disease progression.
C-161 suppressed Th2/Th17-related immune responses in HDM-induced asthmatic mice.

Physicochemical Properties

M.Wt 451.32
Formula C20H16Cl2N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2',3'-dichloro-N-(4-hydroxy-3-(methylsulfonamido)phenyl)-[1,1'-biphenyl]-4-carboxamide

References

1. Guo Z, et al. Immunology. 2025 Jun 12. doi: 10.1111/imm.70003.

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