Chemical Structure : ITRI-E-(S)4046
CAS No.:
2661229-35-0
ITRI-E-(S)4046
(E(S)4046)
Catalog No.: PC-21300Not For Human Use, Lab Use Only.
ITRI-E-(S)4046 (E(S)4046) is a potent, highly specific, dual synergistic inhibitor of myosin light chain kinase 4 (MYLK4) and Rho-related protein kinase (ROCK) with IC50 of 3.2 nM and 25.6 nM for ROCK1 and MYLK4, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ITRI-E-(S)4046 (E(S)4046) is a potent, highly specific, dual synergistic inhibitor of myosin light chain kinase 4 (MYLK4) and Rho-related protein kinase (ROCK) with IC50 of 3.2 nM and 25.6 nM for ROCK1 and MYLK4, respectively.
ITRI-E-(S)4046 potently inhibits myosin light chain (MLC) phosphorylation (pMLC) with IC50 of 50.4 nM in HTM cells.
ITRI-E-(S)4046 exhibits a selective kinase inhibition profile targeting on the AGC kinase subfamily, and MYLK4, shows high specificity against protein kinase A, G, and C families.
ITRI-E-(S)4046 can reduceintraocular pressure (IOP) in normotensive and hypertensive animal models.
Physicochemical Properties
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M.Wt
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306.37
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Formula
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C18H18N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-(4-(1H-pyrazol-4-yl)phenyl)-3-amino-2-phenylpropanamide
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References
1. Yi-Hsun Chen, et al. Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):12.
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