ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels.
ITX-5061 inhibits SR-BI-dependent uptake of HDL-CE in transfected cells, decreases the fractional catabolic rate of HDL-CE and reduced its hepatic uptake in mice.
ITX-5061 inhibits HCVcc and HCVpp infection of primary human hepatocytes and/or human hepatoma cell lines and has minimal effects on HCV RNA replication.
