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IWP-3

Chemical Structure : IWP-3

CAS No.: 687561-60-0

IWP-3

Catalog No.: PC-25594Not For Human Use, Lab Use Only.

IWP-3 is a potent, small molecule inhibitor of Wnt production with IC50 of 40 nM, inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins, inhibits CK1γ3 and CK1ε, does not inhibit CK1α.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IWP-3 is a potent, small molecule inhibitor of Wnt production with IC50 of 40 nM, inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins, inhibits CK1γ3 and CK1ε, does not inhibit CK1α.

Physicochemical Properties

M.Wt 484.58
Formula C22H17FN4O2S3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide

References

1. Baozhi Chen, et al. Nat Chem Biol. 2009 Feb;5(2):100-7.

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