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IWP-L6

Chemical Structure : IWP-L6

CAS No.: 1427782-89-5

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IWP-L6 (IWP L6, Porcupine inhibitor)

Catalog No.: PC-49489Not For Human Use, Lab Use Only.

IWP-L6 is a potent, selective inhibitor of Porcupine with EC50 of 0.5 nM.

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10 mg $68 In stock
25 mg $118 In stock
50 mg $198 In stock
100 mg $348 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IWP-L6 is a potent, selective inhibitor of Porcupine with EC50 of 0.5 nM.
IWP-L6 effectively suppressed the phosphorylation of dishevelled 2 (Dvl2) in HEK293 cells, a biochemical event associated with many Wnt-dependent cellular responses.
IWP-L6 inhibits Wnt mediated branching morphogenesis in cultured embryonic kidneys.

Physicochemical Properties

M.Wt 472.58
Formula C25H20N4O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide

References

1. Wang, X., et al., et al. J Med Chem, 2013. 56(6): p. 2700-4.

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