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Chemical Structure : Iberiotoxin
CAS No.: 129203-60-7
Catalog No.: PC-60654Not For Human Use, Lab Use Only.
Iberiotoxin (IbTX) is a selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM.
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|---|---|---|---|
| 100 ug | $328 | In stock | |
| 500 ug | $548 | In stock | |
| 1 mg | $858 | In stock | |
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Iberiotoxin (IbTX) is a selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM.
Iberiotoxin reversibly blocks PK,Ca in excised membrane patches from bovine aortic smooth muscle.
| M.Wt | 4230 | |
| Formula | C179H274N50O55S7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
H2O: 0.70 mg/ml |
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| Chemical Name/SMILES |
XFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ (Modifications: X-1 = pGlu, Disulfide bridge between 7 - 28,13 - 33,17 - 35) |
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1. Nausch B, et al. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30.
2. Suarez-Kurtz G, et al. J Pharmacol Exp Ther. 1991 Oct;259(1):439-43.
3. Galvez A, et al. J Biol Chem. 1990 Jul 5;265(19):11083-90.
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