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Iberiotoxin

Chemical Structure : Iberiotoxin

CAS No.: 129203-60-7

Iberiotoxin (IbTX)

Catalog No.: PC-60654Not For Human Use, Lab Use Only.

Iberiotoxin (IbTX) is a selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM.

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Biological Activity

Iberiotoxin (IbTX) is a selective, potent peptidyl blocker of the big conductance Ca2+-activated K+ channel (BKCa, KCa1.1, MaxiK) with IC50 of 0.25 nM.
Iberiotoxin reversibly blocks PK,Ca in excised membrane patches from bovine aortic smooth muscle.

Physicochemical Properties

M.Wt 4230
Formula C179H274N50O55S7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

H2O: 0.70 mg/ml

Chemical Name/SMILES

XFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ (Modifications: X-1 = pGlu, Disulfide bridge between 7 - 28,13 - 33,17 - 35)

References

1. Nausch B, et al. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30.

2. Suarez-Kurtz G, et al. J Pharmacol Exp Ther. 1991 Oct;259(1):439-43.

3. Galvez A, et al. J Biol Chem. 1990 Jul 5;265(19):11083-90.

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