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Chemical Structure : Iboxamycin
Catalog No.: PC-21856Not For Human Use, Lab Use Only.
Iboxamycin (IBX) is a broad-spectrum ribosome-binding antibiotic with potent activity against Gram-positive and Gram-negative bacteria overcomes bacterial multidrug resistance.
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Iboxamycin (IBX) is a broad-spectrum ribosome-binding antibiotic with potent activity against Gram-positive and Gram-negative bacteria overcomes bacterial multidrug resistance.
Iboxamycin (IBX) displays activity against a strain of E. coli resistant to cephalosporin, fluoroquinolone, tetracycline and aminoglycoside antibiotics (MIC = 8 μg ml−1) Clinical strains of Neisseria gonorrhoeae isalso highly susceptible (MIC = 0.125 μg ml−1) to Iboxamycin (IBX).
Iboxamycin (IBX) is non-haemolytic and non-toxic towards mammalian cells.
Iboxamycin (IBX) is orally bioavailable, safe and effective in treating both Gram-positive and Gram-negative bacterial infections in mice.
| M.Wt | 495.07 | |
| Formula | C22H39ClN2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Aleksandrova EV, et al. Nat Chem Biol. 2024 Jan 18. doi: 10.1038/s41589-023-01525-w.
2. Mitcheltree MJ, et al. Nature. 2021 Nov;599(7885):507-512.
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