Chemical Structure : Ibrexafungerp citrate
CAS No.: 1965291-08-0
Catalog No.: PC-22726Not For Human Use, Lab Use Only.
Ibrexafungerp (MK 3118, SCY-078) citrate is a novel orally bioavailable fungal beta-1,3-D glucan synthetase inhibitor against Candida species C. glabrata (MIC 0.03 to 0.25 ug/ml), C. parapsilosis (MIC 0.06 to 0.25 ug/ml).
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Ibrexafungerp (MK 3118, SCY-078) citrate is a novel orally bioavailable fungal beta-1,3-D glucan synthetase inhibitor against Candida species C. glabrata (MIC 0.03 to 0.25 ug/ml), C. parapsilosis (MIC 0.06 to 0.25 ug/ml).
Ibrexafungerp (MK 3118, SCY-078) is a novel orally bioavailable fungal beta-1,3-D glucan synthetase inhibitor against Candida species C. glabrata (MIC 0.03 to 0.25 ug/ml), C. parapsilosis (MIC 0.06 to 0.25 ug/ml).
Ibrexafungerp (MK 3118, SCY-078) shows actvity in an in vivo neutropenic murine model.
M.Wt | 922.16 | |
Formula | C50H75N5O11 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
4H-1,4a-Propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid, 15-[(2R)-2-amino-2,3,3-trimethylbutoxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-, (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) |
1. Wring SA, et al. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02068-16.
2. Lamoth F, et al. Antimicrob Agents Chemother. 2015 Jul;59(7):4308-11.
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