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Ibrutinib-biotin

Chemical Structure : Ibrutinib-biotin

CAS No.: 1599432-18-4

Ibrutinib-biotin (Ibrutinib biotin)

Catalog No.: PC-42104Not For Human Use, Lab Use Only.

Ibrutinib-biotin is a chemical probe that consists of Ibrutinib linked to biotin via a long chain linker, has IC50 of 0.755-1.02 nM for Btk kinase.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ibrutinib-biotin is a chemical probe that consists of Ibrutinib linked to biotin via a long chain linker, has IC50 of 0.755-1.02 nM for Btk kinase.
Ibrutinib-biotin extracted from patent WO2014059368A1 Compound 1-5.

Physicochemical Properties

M.Wt 1097.374
Formula C56H80N12O9S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Pentanediamide, N1-[4-[[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-4-oxo-2-buten-1-yl]methylamino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-

References

1. Betty Y. CHANG, et al. Companion diagnostics for tec family kinase inhibitor therapy. WO 2014059368 A1.

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