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Chemical Structure : Icalcaprant
Catalog No.: PC-23099Not For Human Use, Lab Use Only.
Icalcaprant (CVL-354) is a potent, selective kappa opioid receptor (KOR) antagonist with Ki of 1.47 nM and IC50 of 0.042 nM, 31-fold binding affinity selectivity over MOR.
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Icalcaprant (CVL-354) is a potent, selective kappa opioid receptor (KOR) antagonist with Ki of 1.47 nM and IC50 of 0.042 nM, 31-fold binding affinity selectivity over MOR.
Icalcaprant (CVL-354) blocks KOR-mediated motivational deficits in mice, dose-dependently reverses the suppression of progressive ratio responding induced by spiradoline.
CVL-354 dose-dependently reverses KOR and MOR-induced thermal analgesia.
| M.Wt | 406.49 | |
| Formula | C23H26N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patent WO2018096510 A1 2018-05-31.
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