IcatC | CatC inhibitor | Probechem Biochemicals

Chemical Structure : IcatC

IcatC (IcatCXPZ-01, CatC inhibitor)

Catalog No.: PC-23639Not For Human Use, Lab Use Only.

IcatC (IcatCXPZ-01) is a potent, cell-permeable dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C (CatC, DPP1) with IC50 of 15 nM, selective over cathepsine H, K, L, S, NSPs and DPP4.

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Biological Activity

IcatC (IcatCXPZ-01) is a potent, cell-permeable dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C (CatC, DPP1) with IC50 of 15 nM, selective over cathepsine H, K, L, S, NSPs and DPP4.

Physicochemical Properties

M.Wt	481.62
Formula	C25H31N5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-((4-methylpiperazin-1-yl)sulfonyl)-[1,1'-biphenyl]-4-yl)cyclopropyl)butanamide

References

1. Korkmaz B, et al. Biochem Pharmacol. 2019 Jun;164:349-367.

2. Rehm SRT, et al. Sci Rep. 2019 Jul 9;9(1):9925.

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IcatC (IcatCXPZ-01, CatC inhibitor)

Biological Activity

Physicochemical Properties

References

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