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Idarubicin

Chemical Structure : Idarubicin

CAS No.: 58957-92-9

Idarubicin ( 4-Demethoxydaunorubicin;IMI-30;NSC 256439)

Catalog No.: PC-63054Not For Human Use, Lab Use Only.

Idarubicin (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.

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Biological Activity

Idarubicin (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.
Idarubicin inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM.
Idarubicin also induces histone eviction from chromatin.

Physicochemical Properties

M.Wt 497.494
Formula C26H27NO9
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione

References

1. Gewirtz DA, et al. Cancer Chemother Pharmacol. 1998;41(5):361-9.

2. Pang B, et al. Nat Commun. 2013;4:1908.

3. Nitiss JL. Nat Rev Cancer. 2009 May;9(5):338-50.

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