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Idarubicin hydrochloride

Chemical Structure : Idarubicin hydrochloride

CAS No.: 57852-57-0

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Idarubicin hydrochloride (Idamycin, 4-Demethoxydaunorubicin hydrochloride)

Catalog No.: PC-45203Not For Human Use, Lab Use Only.

Idarubicin hydrochloride (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Idarubicin hydrochloride (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.
Idarubicin inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM.
Idarubicin also induces histone eviction from chromatin.

Physicochemical Properties

M.Wt 533.9548
Formula C26H28ClNO9
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, hydrochloride (1:1), (7S,9S)-

References

1. Gewirtz DA, et al. Cancer Chemother Pharmacol. 1998;41(5):361-9.

2. Pang B, et al. Nat Commun. 2013;4:1908.

3. Nitiss JL. Nat Rev Cancer. 2009 May;9(5):338-50.

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