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Chemical Structure : Ilepatril
Catalog No.: PC-60709Not For Human Use, Lab Use Only.
A potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively.
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A potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively; displays good in vitro selectivity over a large variety of targets; restores endothelial function by increasing the ratio of NO to O2- concentration and bioavailability of NO, prevents albuminuria and reduces the incidence and severity of glomerulosclerosis and tubulointerstitial damage in vivo.
Hypertension
Phase 2 Discontinued
| M.Wt | 418.508 | |
| Formula | C21H26N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Weckler N, et al. J Renin Angiotensin Aldosterone Syst. 2003 Sep;4(3):191-6.
2. Schäfer S, et al. Cardiovasc Res. 2003 Nov 1;60(2):447-54.
3. Schäfer S, et al. Diabetologia. 2004 Jan;47(1):98-103.
4. Schäfer S, et al. Eur J Pharmacol. 2004 Jan 26;484(2-3):361-2.
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