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Iloperidone hydrochloride

Chemical Structure : Iloperidone hydrochloride

CAS No.: 1299470-39-5

Iloperidone hydrochloride (HP-873 hydrochloride)

Catalog No.: PC-45233Not For Human Use, Lab Use Only.

An atypical antipsychotic that exhibits high affinity to serotonin 5HT2A (Ki =5.6 nM), dopamine D2 (Ki=6.3 nM) and D3 (Ki=7.1 nM) and noradrenaline α1 receptors (Ki=0.36 nM), moderate affinity for D4 (25 nM), 5HT6 (43 nM), 5HT7 (22 nM), and low affinity for 5HT1A (168 nM), D1 and histamine H1 receptors.

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Biological Activity

An atypical antipsychotic that exhibits high affinity to serotonin 5HT2A (Ki =5.6 nM), dopamine D2 (Ki=6.3 nM) and D3 (Ki=7.1 nM) and noradrenaline α1 receptors (Ki=0.36 nM), moderate affinity for D4 (25 nM), 5HT6 (43 nM), 5HT7 (22 nM), and low affinity for 5HT1A (168 nM), D1 and histamine H1 receptors; is used for the treatment of schizophrenia.

Schizophrenia

Approved

Physicochemical Properties

M.Wt 462.9415
Formula C24H28ClFN2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethanone, 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]-, hydrochloride (1:1)

References

1. Barr AM, et al. Neuropharmacology. 2006 Sep;51(3):457-65.

2. Szewczak MR, et al. J Pharmacol Exp Ther. 1995 Sep;274(3):1404-13.

3. Sainati SM, et al. J Clin Pharmacol. 1995 Jul;35(7):713-20.

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