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Chemical Structure : Imarikiren hydrochloride
Catalog No.: PC-60043Not For Human Use, Lab Use Only.
A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay.
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A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay; displays excellent selectivity against other aspartic proteases, such as pepsin and cathepsin D (IC50>10 uM); exhibits a dramatically improved PK profile in rats, and long-lasting antihypertensive efficacy in vivo.
Diabetes
Phase 2 Clinical
| M.Wt | 536.114 | |
| Formula | C27H42ClN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Imaeda Y, et al. ACS Med Chem Lett. 2016 Sep 12;7(10):933-938.
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