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Imarikiren hydrochloride

Chemical Structure : Imarikiren hydrochloride

CAS No.: 1202269-24-6

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Imarikiren hydrochloride (TAK-272;TAK 272 hydrochloride;TAK272)

Catalog No.: PC-60043Not For Human Use, Lab Use Only.

A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay; displays excellent selectivity against other aspartic proteases, such as pepsin and cathepsin D (IC50>10 uM); exhibits a dramatically improved PK profile in rats, and long-lasting antihypertensive efficacy in vivo.

Diabetes

Phase 2 Clinical

Physicochemical Properties

M.Wt 536.114
Formula C27H42ClN5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(morpholin-4-yl)carbonylpiperidin-3-yl]-1H-benzimidazole-2-carboxamide hydrochloride

References

1. Imaeda Y, et al. ACS Med Chem Lett. 2016 Sep 12;7(10):933-938.

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