You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-Bcr-Abl-Imatinib
Imatinib

Chemical Structure : Imatinib

CAS No.: 152459-95-5

Imatinib (STI571;STI 571;STI-571)

Catalog No.: PC-44438Not For Human Use, Lab Use Only.

Imatinib (STI571) is a multi-kinase inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 uM, 0.1 uM and 0.1 uM in cell-free or cell-based assays.

Packing Price Stock Quantity
50 mg (Free Sample) $28 In stock
250 mg $78 In stock
1 g $138 In stock
5 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Imatinib (STI571) is a multi-kinase inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 uM, 0.1 uM and 0.1 uM in cell-free or cell-based assays.
Imatinib (STI571)  inhibits the SLF-dependent activation of wild-type c-kit kinase activity with IC50 of 0.1 uM.
Imatinib (STI571)  exhibits growth-inhibitory activity on NCI-H727 cell and BON-1 cell with IC50 of 32.4 and 32.8 uM, respectively; active in vivo.

Physicochemical Properties

M.Wt 493.6028
Formula C29H31N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 40 mg/mL

Chemical Name/SMILES

Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-

References

1. Yao JC, et al. Clin Cancer Res. 2007, 13(1), 234-240.

2. Heinrich MC, et al. Blood. 2000, 96(3), 925-932.

3. Druker BJ, et al. Nat Med. 1996 May;2(5):561-6.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: