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Inarigivir

Chemical Structure : Inarigivir

CAS No.: 475650-36-3

Inarigivir (ORI-9020;SB-9000)

Catalog No.: PC-60083Not For Human Use, Lab Use Only.

Inarigivir (ORI-9020, SB-9000) is a dinucleotide that activates RIG-I and NOD2, induces interferon mediated antiviral immune responses.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Inarigivir (ORI-9020, SB-9000) is a dinucleotide that activates RIG-I and NOD2, induces interferon mediated antiviral immune responses.
Inarigivir shows broad-spectrum antiviral activity against RNA viruses including HCV, norovirus, RSV and influenza, and also demonstrates activity HBV in vitro and in vivo.
Inarigivir is a novel agonist of innate immunity.
Inarigivir is the activite componet of Inarigivir soproxil (SB-9200).

Physicochemical Properties

M.Wt 587.5008
Formula C20H26N7O10PS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O-(((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl) O-((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl) S-hydrogen phosphorothioate

References

1. Korolowicz KE, et al. PLoS One. 2016 Aug 23;11(8):e0161313.

2. Suresh M, et al. PLoS One. 2017 Jan 5;12(1):e0169631.

3. Jones M, et al. J Med Virol. 2017 Sep;89(9):1620-1628.

4. Iyer RP, et al. Antimicrob Agents Chemother. 2004 Jun;48(6):2318-20.

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