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Inarigivir soproxil

Chemical Structure : Inarigivir soproxil

CAS No.: 942123-43-5

Inarigivir soproxil (SB-9200;SB9200;Inarigivir;ORI-9020)

Catalog No.: PC-60044Not For Human Use, Lab Use Only.

Inarigivir soproxil (SB-9200, SB9200, Inarigivir, ORI-9020) is an orally bioavailable dinucleotide that activates RIG-I and NOD2, induces interferon mediated antiviral immune responses.

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Purity & Documentation Purity: 96.9% (LCMS) Select Batch:

Biological Activity

Inarigivir soproxil (SB-9200, SB9200, Inarigivir, ORI-9020) is an orally bioavailable dinucleotide that activates RIG-I and NOD2, induces interferon mediated antiviral immune responses.
Inarigivir soproxil (SB-9200) shows broad-spectrum antiviral activity against RNA viruses including HCV, norovirus, RSV and influenza, and also demonstrates activity HBV in vitro and in vivo.
Inarigivir soproxil (SB-9200) is a novel agonist of innate immunity, and prodrug of Inarigivir (ORI-9020;SB-9000).

Physicochemical Properties

M.Wt 703.617
Formula C25H34N7O13PS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(((((2S,3S,5S)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-yl)oxy)phosphoryl)thio)methyl isopropyl carbonate

References

1. Korolowicz KE, et al. PLoS One. 2016 Aug 23;11(8):e0161313.

2. Suresh M, et al. PLoS One. 2017 Jan 5;12(1):e0169631.

3. Jones M, et al. J Med Virol. 2017 Sep;89(9):1620-1628.

4. Iyer RP, et al. Antimicrob Agents Chemother. 2004 Jun;48(6):2318-20.

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