Catalog No.: PC-25140Not For Human Use, Lab Use Only.
Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibit the transcription of PCSK9, inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18, shows anti-inflammatory, lipid-regulating and anti-atherosclerotic activities.
Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibit the transcription of PCSK9, inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18, shows anti-inflammatory, lipid-regulating and anti-atherosclerotic activities.
Physicochemical Properties
M.Wt
16339 (1 mg= 61nmol, 5 mg= 306nmol)
Formula
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
RNA, (Am-sp-(2'-deoxy-2'-fluoro)C-sp-Am-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'- fluoro)A-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)AAm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-Am-Gm-sp-Am-sp-Am), complex with RNA (Cm-sp-Umsp -Am-Gm-Am-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Um-dT-UmUm-Gm-Cm-Um-Um-Um-Um-Gm-Um) 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2- deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2
References
1. Constantine E Kosmas, et al. Ther Clin Risk Manag. 2020 Oct 28;16:1031-1037.
