Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Indirubin E804
CAS No.: 854171-35-0
Catalog No.: PC-61235Not For Human Use, Lab Use Only.
Indirubin E804 is an indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Indirubin E804 is an indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro.
E804 decreases tyrosyl phosphorylation of Stat3, suppresses constitutive Stat3 DNA binding-activity in treated cells, also down-regulates antiapoptotic proteins Mcl-1 and Survivin.
E804 inhibits the subintestinal vessels formation in zebrafish embryos.
| M.Wt | 365.389 | |
| Formula | C20H19N3O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-[3-[(3,4-Dihydroxybutoxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one |
|
1. Nam S, et al. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5998-6003.
2. Zhou J, et al. Blood. 2009 Apr 23;113(17):4052-62.
3. Chan YK, et al. Biochem Pharmacol. 2012 Mar 1;83(5):598-607.
4. Nam S, et al. Mol Oncol. 2012 Jun;6(3):276-83.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
