Catalog No.: PC-62314Not For Human Use, Lab Use Only.
Indisulam (E7070) is potent, sulfonamide, carbonic anhydrase inhibitor with Ki values of 31, 15, and 24 nM against human carbonic anhydrase I, II, and IX, and RBM39 molecular glue degrader via DCAF15.
Indisulam (E7070) is potent, sulfonamide, carbonic anhydrase inhibitor with Ki values of 31, 15, and 24 nM against human carbonic anhydrase I, II, and IX, and RBM39 molecular glue degrader via DCAF15.
Indisulam (E7070) possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines.
Indisulam (E7070) promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase complex, triggering polyubiquitination and proteasomal degradation of RBM39.
Indisulam causes blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E, shows activity in multiple tumor types, most prominently in colon and lung cancer.
Physicochemical Properties
M.Wt
385.85
Formula
C14H12ClN3O4S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide
References
1. van Kesteren C, et al. Br J Clin Pharmacol. 2002 Nov;54(5):463-71.
2. Owa T, et al. J Med Chem. 2002 Oct 24;45(22):4913-22.
3. Ozawa Y, et al. Eur J Cancer. 2001 Nov;37(17):2275-82.
4. Tsukahara K, et al. Mol Pharmacol. 2001 Dec;60(6):1254-9.
