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Chemical Structure : Indisulam
CAS No.: 165668-41-7
Catalog No.: PC-62314Not For Human Use, Lab Use Only.
Indisulam (E7070) is potent, sulfonamide, cell-cycle inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg (Free Sample) | $18 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | Get quote |
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Indisulam (E7070) is potent, sulfonamide, cell-cycle inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines.
Indisulam (E7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15
Indisulam causes blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E, shows activity in multiple tumor types, most prominently in colon and lung cancer.
| M.Wt | 385.85 | |
| Formula | C14H12ClN3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide |
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1. van Kesteren C, et al. Br J Clin Pharmacol. 2002 Nov;54(5):463-71.
2. Owa T, et al. J Med Chem. 2002 Oct 24;45(22):4913-22.
3. Ozawa Y, et al. Eur J Cancer. 2001 Nov;37(17):2275-82.
4. Tsukahara K, et al. Mol Pharmacol. 2001 Dec;60(6):1254-9.
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