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Ipragliflozin

Chemical Structure : Ipragliflozin

CAS No.: 761423-87-4

Ipragliflozin (ASP1941, ASP-1941)

Catalog No.: PC-44115Not For Human Use, Lab Use Only.

Ipragliflozin (ASP1941) is a highly potent and selective SGLT2 inhibitor with IC50 of 14 nM for hSGLT2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ipragliflozin (ASP1941) is a highly potent and selective SGLT2 inhibitor with IC50 of 14 nM for hSGLT2.
Ipragliflozin shows 254-fold selectivity over hSGLT1.
Ipragliflozin reduces blood glucose levels in a dose-dependent manner in diabetic models KK-A(y) mice and STZ rats.

Physicochemical Properties

M.Wt 404.4518
Formula C21H21FO5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

D-Glucitol, 1,5-anhydro-1-C-[3-(benzo[b]thien-2-ylmethyl)-4-fluorophenyl]-, (1S)-

References

1. Imamura M, et al. Bioorg Med Chem. 2012 May 15;20(10):3263-79.

2. Tahara A, et al. J Pharmacol Sci. 2012;120(1):36-44.

3. Tahara A, et al. Eur J Pharmacol. 2013 Sep 5;715(1-3):246-55.

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