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Chemical Structure : Irampanel
Catalog No.: PC-61709Not For Human Use, Lab Use Only.
Irampanel (BIIR 561) is a combined antagonist of AMPA receptors (AMPAR) and voltage-dependent sodium channels.
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Irampanel (BIIR 561) is a combined antagonist of AMPA receptors (AMPAR) and voltage-dependent sodium channels; noncompetitively inhibits AMPA receptor-mediated membrane currents in cultured cortical neurons with IC50 of 8.5 uM, reduces sodium currents in voltage-clamped cortical neurons with IC50 of 5.2 uM and inhibits the veratridine-induced release of glutamate from rat brain slices with IC50 of 2.3 uM; shows anticonvulsive and neuroprotective properties in mice.
| M.Wt | 309.362 | |
| Formula | C18H19N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Weiser T, et al. J Pharmacol Exp Ther. 1999 Jun;289(3):1343-9.
2. Weiser T, et al. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):419-26.
3. Wienrich M, et al. Br J Pharmacol. 2001 Jul;133(6):789-96.
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