Chemical Structure : Irampanel hydrochloride
CAS No.:
206260-34-6
Irampanel hydrochloride
(BIIR561 CL; BIIR561 hydrochloride)
Catalog No.: PC-61710Not For Human Use, Lab Use Only.
Irampanel (BIIR 561) is a combined antagonist of AMPA receptors (AMPAR) and voltage-dependent sodium channels.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Irampanel (BIIR 561) is a combined antagonist of AMPA receptors (AMPAR) and voltage-dependent sodium channels; noncompetitively inhibits AMPA receptor-mediated membrane currents in cultured cortical neurons with IC50 of 8.5 uM, reduces sodium currents in voltage-clamped cortical neurons with IC50 of 5.2 uM and inhibits the veratridine-induced release of glutamate from rat brain slices with IC50 of 2.3 uM; shows anticonvulsive and neuroprotective properties in mice.
Physicochemical Properties
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M.Wt
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345.827
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Formula
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C18H20ClN3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N,N-Dimethyl-N-[2-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenoxy]ethyl]amine hydrochloride
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References
1. Weiser T, et al. J Pharmacol Exp Ther. 1999 Jun;289(3):1343-9.
2. Weiser T, et al. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):419-26.
3. Wienrich M, et al. Br J Pharmacol. 2001 Jul;133(6):789-96.
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