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Chemical Structure : Irdabisant
CAS No.: 1005402-19-6
Catalog No.: PC-61615Not For Human Use, Lab Use Only.
Irdabisant (CEP-26401) is a potent, selective, orally active histamine H3 receptor antagonist with Ki of 2 nM and 7 nM for human and rat H3Rs, respectivity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $568 | In stock | |
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| 100 mg | Get quote |
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Irdabisant (CEP-26401) is a potent, selective, orally active histamine H3 receptor antagonist with Ki of 2 nM and 7 nM for human and rat H3Rs, respectivity.
Irdabisant (CEP-26401) displays >1,000-fold selectivity over the H1R, H2R, and hH4R subtypes.
Irdabisant (CEP-26401) dose-dependently inhibits H3R agonist-induced dipsogenia in the rat (ED50=0.06 mg/kg po).
vexhibits cognition-enhancing and wake-promoting activities in mice.
| M.Wt | 313.401 | |
| Formula | C18H23N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one |
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1. Hudkins RL, et al. J Med Chem. 2011 Jul 14;54(13):4781-92.
2. Raddatz R, et al. J Pharmacol Exp Ther. 2012 Jan;340(1):124-33.
3. Spiegelstein O, et al. J Psychopharmacol. 2016 Oct;30(10):983-93.
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